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[100] have suggested that inhibition of myocardial CPT I activity may be a common feature of systemic inflammation, or of inflammation localized to the heart
A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity
However, stress, pollution, smoking, toxins, poor diet, inflammation, and ageing can increase their production
J Physiol 581:431444 Strijbis K, Vaz FM, Distel B (2010) Enzymology of the carnitine biosynthesis pathway
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