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Research indicates both topical and intraperitoneal administration routes produced similar wound healing effects in animal models
For broader stacking-safety context see the PepPal side-effects guide
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Pickart and colleagues documented that GHK-Cu influences the expression of over 4,000 human genes, with significant upregulation of genes involved in collagen synthesis, DNA repair, and antioxidant defense [1]
A clinical trial of 71 women with mild to advanced photoaging found that daily application of a GHK-Cu facial cream for three months significantly increased skin density and thickness, reduced sagging, and improved the appearance of fine lines and wrinkles compared to placebo
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