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Blood 94 , 29552962 (1999)
Townsend EC, Murakami MA, Christodoulou A, Christie AL, Koster J, DeSouza TA, et al
Part Two: Decreasing DHT By Inhibiting 5-Alpha Reductase Review: Three Levers Of DHT Reduction Remember: in order for dihydrotestosterone (DHT) to form, we need all of the following present: Free testosterone 5-alpha reductase Androgen receptors As a result, this gives us three major levers to reduce DHT levels: decrease 1) free testosterone, 2) 5-alpha reductase, and / or 3) androgen receptors
No receptor-mediated adverse events (e.g., cardiovascular effects, endocrine disruption) have been reported, consistent with NNMT's limited expression outside metabolic tissues