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doi: 10.1016/S0140-6736(87)91361-4 36 HirschECBrandelJ-PGallePJavoy-AgidFAgidY

Sub-99% material introduces unknown variables uncharacterized impurity peaks may have their own biological activity or confound assay readouts

In tumor cells, pyroptosis is regulated by multiple pathways and factors, which can be broadly classified into three major mechanisms: the classical inflammasome pathway (caspase-1-dependent), the nonclassical inflammasome pathway (dependent on caspase-4/-5 in humans and caspase-11 in mice), and a caspase-3-dependent pathway

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