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Temporary S-glutathionylation of enzymes in the TCA cycle, ETC, or -oxidation pathway protects them from irreversible oxidation when ROS is high but may also hypothetically serve as a mechanism to diminish mitochondrial ROS production by reducing their activity [51]

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Prof Jebb added that people paying privately for the drugs need to be aware of the very high risk of rapid weight regain when treatment ends so they can make decisions about long-term treatment aware of the financial consequences

Reducing the risk of cardiovascular events such as stroke, non-fatal myocardial infarction, or stroke in patients with or without type 2 diabetes mellitus

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