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(Thus, our goal was to design a peptide agonist that overcomes these shortcomings and compare glucoregulation/appetite control driven by the incorporation of Y1-R/Y2-R agonism, a property not shared by tirzepatide incorporation

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Both compete for the same MC3R and MC4R binding sites, which is why simultaneous administration creates receptor saturation and side effect amplification rather than additive functional benefit

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