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The Risks of Semaglutide and Tirzepatide for Weight Loss While GLP-1 agonists are generally well-tolerated, Kansas City semaglutide and tirzepatide have potential side effects and risks

Dejgaard TF, Schmidt S, Frandsen CS et al (2020) Liraglutide reduces hyperglycaemia and body weight in overweight, dysregulated insulin-pump-treated patients with type 1 diabetes: the Lira Pump triala randomized, double-blinded, placebo-controlled trial

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Participants were randomly assigned to receive retatrutide (4 mg, 9 mg, or 12 mg) or placebo by once-weekly subcutaneous injection (134, 133, 136, and 134 individuals, respectively).The researchers found that for the treatment regimen estimand, the mean change from baseline in hemoglobin A1c concentration was 1.69, 1.86, and 1.94 percent with 4, 9, and 12 mg of retatrutide, respectively, versus 0.81 percent with placebo, resulting in estimated treatment differences of 0.88, 1.04, and 1.12 percent, respectively, versus placebo

10.1038/s41598-019-50798-6 18 Changgui LiM.-C