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The effect of semaglutide compared to placebo on estimated diastolic blood pressure was calculated using a MMRM model with two-sided P-values and with fixed effects for treatment, visit, baseline log-transformed UACR, the interaction between treatment and visit, and the interaction between baseline and diastolic blood pressure

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J Pharm Investig 51:611634 Shah SA, Yoon GH, Chung SS, Abid MN, Kim TH, Lee HY, Kim MO (2017) Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimers disease neuropathological deficits