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Animal studies show substantial evidence across stroke models (full functional recovery in spatial memory, motor coordination, balance), Parkinsons models (protection of dopaminergic neurons, near-complete prevention of mortality), multiple sclerosis models (significantly less brain damage), and traumatic brain injury (reduced hemorrhage and edema)

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RSL3 increased oxidized membrane lipid levels, as measured by confocal and flow cytometry using the dye C11-BODIPY in CRC DTP cells compared to the parental cells, supporting the notion of increased susceptibility of CRC persister cells to ferroptosis after 5-FU or AZ628 treatment ( Figures 3G, H )

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