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Interestingly, decreased expression of hephaestin and FPN and increased expression of hepdicin (a protein that promote FPN degradation) suggest these cells accumulate iron and this may contribute to disease worsening

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Liu, J., Deng, Z., Zhu, X., Zeng, Y., Guan, X., & Li, J

In this study, we demonstrate that human albumin requires a branched or medium-long aliphatic amino acid in the C-terminal end at position 585 for optimal binding to human FcRn, and that the L585 residue can not be substituted with an amino acid unrecognizable by CPA without compromising receptor binding

The process involves multiple steps, coverage checks, and provider reviews before approval, so it doesnt move at telehealth speed