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45, 2021;Puhl, R

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CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]

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468,469 Moreover, therapeutic interventions targeting metabolic pathways, oxidative stress, and inflammation are being explored to prevent or slow the progression of CAN

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The clinical data on how common menstrual changes are The SURMOUNT-1 and SURMOUNT-2 trials enrolled women of reproductive age but didn't specifically track menstrual cycle changes as a primary endpoint

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