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Because MOTS-c is a regulator of metabolic homeostasis that prevented high-fat diet (HFD)-induced obesity and insulin resistance 15 , we tested if MOTS-c also improved running performance under metabolic (dietary) stress

Monitoring and Follow-Up Establish a structured monitoring schedule: Monthly visits during dose titration and the first 6 months Quarterly visits once stable, assessing weight, tolerability, and metabolic parameters Annual comprehensive evaluation including lipid panel, HbA1c (if diabetic), liver function tests, and cardiovascular risk assessment Regular monitoring allows early identification of plateaus, adverse effects, or emerging medical issues that may require intervention

Current evidence is insufficient to provide clear recommendations on the optimal drug cessation before elective surgery

ALT and AST enzyme levels normalize in many patients

Patient guidance aligns with this timeframe, noting that effects taper as the drug slowly declines, which is why weekly dosing maintains steady benefits