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Mistake 4: shaking the vial to mix Vigorous shaking creates foam and physical shearing forces that can denature the peptide

But there's a broader picture to paint here

As evidence of the efficacy of SGLT-2 inhibitors continued to grow, trials on these drugs have expanded their study populations from diabetes patients only to also include patients with HF or CKD in the absence of diabetes

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And separately, a key Canadian patent lapsed permanently after Novo Nordisk failed to pay a $250 CAD maintenance fee back in 2019