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Disadvantage: long-term efficacy beyond 48 weeks still being studied in Phase 3 trials

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Second, translational development should focus on dual-functional nanocarriers incorporating A-targeting peptides and RVG29 brain-homing peptides, delivering GPX4 activators or iron chelators with pH/ROS-responsive release to ensure lesion-specific delivery and avoid neurotransmitter synthesis impairment from non-specific iron depletion

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Future research integrating standardized fermentation systems with well-controlled clinical investigations will be essential to bridge the gap between preclinical promise and practical application