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Prescriptions for semaglutide and tirzepatide among patients with PCOS Between 2021 and 2025, 445,258 patients with PCOS had at least one medical encounter, of whom 90,206 (20.3%) received a semaglutide or tirzepatide prescription during the study period

This is of particular importance in the case of Adrenal Exhaustion because it is the dysregulation of the messengers of these two systems, namely adrenaline (also called epinephrine) in the case of AHS and norepinephrine (also called noradrenaline) in the case of SNS, that is the hallmark of Phase C Adrenal Exhaustion symptoms

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