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Glutathione depletion as a consequence occurs in: active chronic infection (Epstein-Barr reactivation, chronic hepatitis B/C, HIV, tuberculosis, Lyme co-infections), uncontrolled diabetes with HbA1c above 8.5%, ongoing heavy metal exposure (occupational, dental amalgam in symptomatic individuals, contaminated water), persistent mold biotoxin exposure, untreated obstructive sleep apnea with nocturnal hypoxia, and chronic NSAID, acetaminophen, or alcohol use

Matek D, Sikiric P, et al

Concurrently, increased sperm abnormalities, a consequence of oxidative stress-induced damage, further impede fertilization potential