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Once you add bacteriostatic water, you introduce the solvent that enables hydrolytic degradation

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Finally, while the expanding research into additional indications is promising, patients should be aware that off-label use for conditions like sleep apnea or cognitive decline lacks the rigorous evidence supporting approved indications

Just how much of a challenge this posed can be gauged from the fact that Mutt's group needed 10km of porcine small intestine to obtain about 1mg of pure secretin (Rehfeld 2012)