Mutation of allosteric hot spot residues alter the allosteric communications In order to examine how the triangular allosteric network responds to the mutations of key residues, we have prepared three GDH mutants in silico using Chimera rotamers tools 29 GDH Ser441Leu , GDH Arg217Cys , and GDH Gly376Asp
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Patients who responded to the drug compared to those who did not, had significant differences in baseline levels as well as in the trajectories of several metabolites, including several gutmicrobiota related metabolites, suggesting that the drug exposure might be impacting gut-microbial ecology differently in the two groups
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