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Oral peptides: Most peptides marketed as oral supplements (gummies, capsules) have poor bioavailability because the digestive tract breaks them down

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.The handling editor declared a past co-authorship with the authors

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Implications for Treatment Decisions For diabetic patients with kidney disease or elevated risk: Consider GLP-1 medications early: Rather than waiting for kidney disease to progress, starting GLP-1 treatment may help preserve kidney function

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