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Glutathione S-transferase and glutathione peroxidase expression in normal and tumour research-subject tissues
a 2025 IV pilot in two adults used 10 mg and 20 mg single infusions and reported no adverse effects (Lee et al., Alternative Therapies in Health and Medicine)
Such alterations in OXPHOS levels may be connected to misfunctions in the oxidative phosphorylation process, in accordance with a study reporting that a pharmacologically induced 5-HTT inhibition damaged the activity of the supercomplexes ( In line with the OXPHOS dysregulation, we found that 5-HTT / animals showed a significant decrease in antioxidant enzyme Cat mRNA levels in the amygdala and prefrontal cortex and increased expression of Gpx1 in the amygdala, possibly indicating an alteration of the activity of these enzymes to cope with the possible increase of ROS, due to the OXPHOS alteration
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