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267 , L414L421 (1994)
Hultman American Journal of Physiology-Endocrinology and Metabolism 1994 266:5, E725-E730 Baker JS, McCormick MC, Robergs RA
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PMC 8622150
A TEST OF THE SAME DOSE OF A FINE AND A COARSE AEROSOL IN DOG SURPRISINGLY INDICATED NEGLIGIBLE INTRANASAL FILTRATION Mikael Brlls 1, Steven Oag1 & Eva Lamm Bergstrm1 1AstraZeneca BioPharmaceuticals R&D, AstraZeneca R&D Gothenburg, Mlndal, SE431 83, Sweden Summary: A novel inhalation exposure system was developed to increase the efficiency of pharmacokinetic (PK) evaluations of inhaled drugs in a large species such as the dog by enabling simultaneous administration of multiple drugs to the same animal in a single experiment, facilitating a direct comparison of the same lung dose of different drugs using the same blood samples, which can be considered to be a refinement measure from an animal research perspective
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