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Cardiovascular and Endothelial Benefits GLP-1 RAs have demonstrated robust cardiovascular protection in multiple large-scale trials, including LEADER, REWIND, and SUSTAIN-6, showing reduced rates of major adverse cardiac events independent of weight loss
A common side effect of semaglutide is constipation, which can be uncomfortable and affect overall health
For information on recommended timing of when to stop GLP1-RAs prior to pregnancy please see Glucagon-like peptide-1 receptor agonists during pregnancy and lactation
No commercially available injection device exists in the UK as the medicine is not yet licensed
Figure 2: Distribution of Change from Baseline in Mean Monthly Migraine Days by Treatment Group in Study 1 Chronic Migraine Study 2 (NCT 02621931) included adults with a history of chronic migraine (patients with 15 headache days per month)
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