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In the -cell, PC1/3 is up-regulated, resulting in increased processing of proglucagon to GLP-1 while DPP-4 is down-regulated in order to reduce degradation and enhance local intact GLP-1 concentrations
Its a small tripeptide bound to a copper ion, and it was first identified in human plasma decades ago
A: Current research suggests risks like pancreatitis, kidney problems, and muscle loss may increase with prolonged use
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PubMed 6
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