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Leptin signals energy sufficiency to the brain

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By modulating the expression of these genes, it may be possible to enhance the ACLs resilience to mechanical stress and reduce the risk of injury

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28 Electrical stimulation has also been shown to enhance mitochondrial biogenesis by activating peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key regulator of energy metabolism and mitochondrial function in regenerating tissues