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Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis
The first reaction involves the enzyme deoxyhypusine synthase which transfers the butylamine moiety from spermidine to the specific eIF-5A lysine residue
GLP-1 medications cause constipation by slowing gastric emptying and overall gut transit time Macrogol preparations retain water in stool and are recommended for long-term use with GLP-1 therapy Bulk-forming laxatives like ispaghula husk are first-line treatment according to NICE guidance Adequate hydration (1.52 litres daily) is essential when using laxatives with GLP-1 medications Patients should seek medical advice if constipation persists beyond 12 weeks despite treatment Table of Contents Have questions about Wegovy
Lancet (2022) 399:220011
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