Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear
Clinicians should monitor for gallbladder disease, pancreatitis symptoms, dehydration-related acute kidney injury, heart rate increase, diabetic retinopathy worsening in patients with diabetes and rapid glycemic improvement, and dysesthesia-associated adverse events at higher doses
Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway
For these reasons, the DG muscle is no longer recommended for IM injections in spite of this, many nurses continue to use it (Ogston-Tuck,2014
Diabetics should coordinate any peptide use with their healthcare team