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In clinical trials, these medications have produced significant results

John found that exenatide is an analog of human GLP-1RA, with 53% homology to human GLP-1RA

Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)