Ozeki, Y., Masaki, T., Kamata, A., Miyamoto, S., Yoshida, Y., Okamoto, M., Gotoh, K., & Shibata, H
Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X)
doi: 10.1007/s11154-021-09669-7 8 GriecoMGiorgiAGentileMCdErmeMMoranoSMarasBet al
This "inside-out" approach is far more effective than topical treatments alone, which often cannot penetrate deep enough to affect the skins structural matrix
nevertheless, safety reports of topical solutions note sedation and related central nervous system adverse reactions in a minority of patients, occasionally requiring dose adjustment or discontinuation 5