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of these, most of the candidates target metabolic disorders, such as Type 2 diabetes and obesity

(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

doi:10.1002/pmic.200800989

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Start with weights that feel manageable and focus on form for the first two weeks, then begin adding weight incrementally