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In neurodegenerative conditions, astrocytic dysfunction can disrupt the metabolic support of neurons, aggravate excitotoxicity by limiting glutamate uptake, and alter synaptic function, all of which exacerbate neuronal loss and cognitive decline ( 3.3 Infiltration of peripheral immune cells Peripheral immune cells such as Neutrophils, Monocytes, NK cells, Dendritic cells, T-cells, and even B-cells play crucial roles in the immune response (Turner and Sharp, 2016)

The peptide is not FDA-approved for any indication, and carriers do not reimburse off-label peptide therapy regardless of the clinical justification

SURMOUNT-4 (N=670) demonstrated that patients who completed titration and then continued maintenance tirzepatide maintained 18.2% body weight loss at 88 weeks, compared to 2.5% in the withdrawal group [11]

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Under medical supervision, tirzepatide has shown remarkable benefits in helping patients not only manage their blood sugar but also experience significant, sustainable weight loss by naturally reducing calorie intake and promoting a sense of fullness after smaller meals