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Similarly, metformin administration commonly induces gastrointestinal disturbances, manifesting as diarrhea, abdominal distension, and nausea 12 , with potentially severe complications including lactic acidosis in rare instances 13
Trends Endocrinol Metab 22:2433 Tiano JP, Delghingaro-Augusto V, Le May C et al (2011) Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes
Appetite reduction is often the earliest noticeable effect, reported within the first one to two weeks due to GLP-1 activity on hypothalamic satiety signalling
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