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Research, including recent findings from the SELECT trial, indicates that GLP-1 agonists like semaglutide can significantly reduce the risk of major cardiovascular events, such as heart attacks and strokes, especially in individuals with obesity but without diabetes
However, it suggested that a ureido residue with its side chain shifted to the second backbone methylene (i.e
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These areas remain the focus of laboratory and preclinical research aimed at advancing scientific understanding of peptide biology, cellular signaling, and molecular pharmacology
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