Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy
In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)
It has been investigated as a treatment for growth hormone deficiency and lipodystrophy, reaching phase II clinical trials that were discontinued for reasons unrelated to administration of the peptide
This upregulation is not only a marker of immune cell activation, but also serves as a functional participant in the immune response, modulating cell survival, cytokine production, and peripheral immune cell migration (143, 144)
Topical creams containing menthol or capsaicin provide localized relief