The primary body discusses existing data, mechanisms, and pragmatic considerations for reproductive utilization
According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver
Potency and PK anchors: Lau 2015 (cAMP EC50 6.2 pmol/L), Boianelli 2024 (free fraction 0.36%), FDA 2021 (weight-change EC50 54.6 nmol/L)
Understanding B12 Storage Long-Term Stores: The body, particularly the liver, can store a significant amount of B12
Uv and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement