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Patients should be counseled about potential gastrointestinal AEs which are usually transient and mild to moderate in severity [Citation70,Citation86]

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The problem with lowering the dose of insulin in combination with having a SGLT-2 inhibitor on board is that the levels of ketones start to rise and push some people to DKA, a life-threatening complication, Mathieu said, adding that DKA primarily occurred in people who had a lower body weight, were on insulin pumps, or had a pump catheter obstruction

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