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Intra-articular injection of a GLP-1R antagonist, exendin 9-39 amide, abolished the therapeutic effects of GUDCA on osteoarthritis, which indicates that L cellderived GLP-1 entered the joint to ameliorate osteoarthritis progression
doi:10.1159/000359974
Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1998 Feb;85(2):135-41
Its oral bioavailability is achieved through the incorporation of the absorption enhancer SNAC (N-[8-(2-hydroxybenzoyl)amino]octanoic acid), which works through two mechanisms: (1) temporarily raising the local pH in the stomach to reduce gastric protease activity
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