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The PERK inhibitor GSK2606414 reduces neurodegeneration in prion disease and tauopathy models, 416 while ISRIB restores protein synthesis and attenuates neurodegeneration in AD models
It's peer-reviewed
Intracellular ROS oxidise the thiol linkages in cysteine residues of proteins including kinases and phosphatases, ultimately affecting the growth factors, cytokines, and hormones
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In a more complex murine CRC model, we used orthotopic endoscopy-guided submucosal injection 24,25,26 of 4-hydroxytamoxifen to drive allelic recombination in AKP mice and promote tumour formation
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