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In contrast, the prolyl isomerase cyclophilin D in the mitochondrial matrix is an essential regulator of MPT and the only genetically proven indispensable MPT component (Nakagawa et al., 2005

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The MGF E-peptide has been shown to significantly increase the proliferative lifespan and delay senescence of satellite cells isolated from neonatal and young adult human muscle, while having attenuated effects in cells from older adults establishing an age-dependent satellite cell responsiveness to MGF that underpins its utility as a sarcopenia and muscle ageing research tool