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A systematic review and meta-analysis finds that GLP-1-based treatments drive clinically meaningful weight loss mainly through fat reduction, but experts warn that preserving muscle remains essential for long-term metabolic health

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What factors could limit the widespread adoption of GLP-1 receptor agonists despite their proven benefits in HbA1c reduction, weight loss, and cardiovascular risk management, and how might healthcare systems address these barriers

Long-acting systemic GLP-1 analogs (liraglutide, semaglutide) are obtained by reversibly binding to albumin