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4.2 Autoimmune diseases Autoimmune diseases (AIDs) are a group of disorders in which the immune system develops an immune response to its own normal tissue components (189), characterized by chronic, systemic, and excessive immune activation and inflammation, ultimately leading to organ destruction or dysfunction (190)

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Research has found that stress hormones impair the production of glutathione in the mitochondrial by dramatically increasing mitochondrial oxygen consumption and reactive oxygen species formation or by increasing glutathione exchange between mitochondria and the cytosol

The Phase II trials studied a topical ophthalmic solution of full-length T4 for dry eye, and even there the results were mixed on the primary endpoints

Glutathione exists in redox equilibrium between disulfide (GSSG, oxidized form) and sulfhydryl (GSH, reduced form) forms and GSH levels in the living cells alter remarkably in response to the oxidative stress, which has been involved in many diseases and speeds up the aging process 5,6