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Funding This research received no external funding

10 Agency EM

For comparative melanocortinic pharmacology research, it remains a historically relevant reference

Figure 3 4.3 Ectopic lipid deposition Ectopic lipid deposition represents a critical physical manifestation of systemic metabolic dysregulation, wherein lipid overflow from dysfunctional adipose tissue infiltrates and compromises non-adipose organs, thereby directly linking the pathogenesis of sarcopenia and atherosclerosis (90, 91)