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Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis
doi: 10.3945/jn.115.210427 94 FratianniFRiccardiRSpignoPOmbraMNCozzolinoATremontePet al
Studies done on obese mice show that GIP may help burn more energy and reduce fat build-up
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While the PARS1 inhibitor halofuginone exhibited toxicity, its optimized derivative DWN12088 demonstrated improved safety and efficacy in preclinical models and is currently under clinical investigation for IPF [143]
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