Any administration in a research setting would need to be part of a carefully designed, ethically reviewed study, with meticulous monitoring for unforeseen interactions or effects
This is consistent across trials and appears to be related to the glucagon component's metabolic effects
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Nrregaard PK, Deryabina MA, Shelton PT et al (2018) A novel GIP analogue, ZP4165, enhances glucagon-like peptide-1-induced body weight loss and improves glycaemic control in rodents
Se ha visto tambin, que el tratamiento con capsaicina, que produce ablacin selectiva de neuronas ganglionares y del nervio vago, bloquea totalmente el efecto anorxico de la administracin del agonista de GLP-1R en roedores (32)