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On the other hand, exogenous BCAA supplementation can also promote pro-inflammatory responses: for example, in specific models, BCAA loading can activate the IFN- receptor 1 (IFNGR1)/Janus kinase 1 (JAK1)/ STAT1 axis and enhance the expression of M1-related genes and the secretion of inflammatory factors ( At the molecular level, the coupling of BCAAs with mTORC1 signaling provides a key clue for understanding their pro-inflammatory effects
PMID 4980931
Schizophr Bull 25 : 763775
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This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources
