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Early responders may notice improved skin texture and reduced fine lines at 4 weeks, but measurable collagen density increases require 812 weeks of sustained therapeutic dermal concentration which SubQ maintains far better than IM
Thromb Res 129: 652659
Conclusion: Glutathione is safe, tolerable and effective whitening agent when used in topical cream (2%) and also in oral form in treatment of melasma.
The volume depends on the target working concentration
