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The GLP-1 hormones job is to stimulate beta cells in the pancreas to secrete insulin

The medication slows stomach emptying and signals the brain to reduce hunger

If you have a higher BMI, you might see larger total pounds lost, while someone with a lower BMI could see a higher percentage drop

In the landmark SURMOUNT-1 trial, participants on the highest dose lost an average of 22.5% of their body weight over 72 weeks, but that loss accumulated steadily over time rather than all at once

Medicare does NOT cover Zepbound for weight loss because federal law prohibits Medicare from covering drugs used primarily for weight management