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It acts as a highly active metabolic organ, regulating vascular tone, blood pressure, and the prevention of abnormal blood clotting

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Epidemiology Gamma-glutamyl transpeptidase deficiency is a very rare disease, which has been reported in seven patients in five families worldwide [3337]

For the inhibition assay, the concentrations of substrates in the cell lysate treated with different concentrations of inhibitors were determined via LC-MS, and the calculation methods for the uptake rate and UR were similar to those in the substrate assay