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Unlike native IGF-1, this analog features a 13-amino acid N-terminal extension and an arginine substitution at position 3, conferring reduced affinity for insulin-like growth factor binding proteins (IGFBPs) and thus increased biological activity across multiple experimental models

Nephron 140 , 917 (2018)

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The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins

The HBEC cells were cultured in K-SFM, and the other cells were cultured in DMEM essential medium with 10% fetal calf serum at 37 C in a humidified incubator in an atmosphere of 95% air and 5% CO 2