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A 2026 systematic review in the European Journal of Endocrinology found GLP-1 receptor agonists were associated with modest short-term weight loss in women with PCOS and overweight or obesity
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Data reveal that early non-responders receiving phentermine achieved 5.9% weight loss compared to just 2.8% with placebo after 24 weeks, with over half reaching the clinically meaningful threshold of 5% weight reduction
These challenges led to widespread shortages across nearly the entire class of GLP-1 medications
