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Calcif Tissue Int (2015) 97(2):10412.10.1007/s00223-015-9993-5 21 DriessenJHvan OnzenoortHAStarup-LindeJHenryRBurdenAMNeefCet alUse of glucagon-like-peptide 1 receptor agonists and risk of fracture as compared to use of other anti-hyperglycemic drugs
Injectable peptides administered subcutaneously reach systemic circulation and target tissues at therapeutic concentrations
In Figures 5C and D , Sema bolus and PNP-1-10-0.05 Sema-1.8 mg/mL hydrogel both induced reductions in blood glucose, but the hydrogel formulation ( Figure 5D ) exhibited more durable glycemic control over time, with lower inter-animal variability
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